時(shí)光荏苒，作為婦產(chǎn)醫(yī)生已經(jīng)能夠獨(dú)當(dāng)一面的鴻鳥(niǎo)櫻來(lái)到了曾經(jīng)的恩師荻島勝秀所在的離島醫(yī)院?？粗蛵u上居民近距離接觸的荻島的身影，櫻開(kāi)始思考一件事情。
　　另一方面，曾經(jīng)是研修醫(yī)的下屋和新生兒科的白川都成為了專業(yè)醫(yī)師繼續(xù)工作著。
　　從離島歸來(lái)的櫻和助產(chǎn)士小松一起診察了耳朵聽(tīng)不見(jiàn)的孕婦早見(jiàn)愛(ài)菜。她的丈夫健治也有一同前來(lái)，但健治是一位聾啞人。因?yàn)獒t(yī)療術(shù)語(yǔ)用手語(yǔ)或者唇語(yǔ)都很難傳達(dá)，所以改用了白板進(jìn)行筆談。
　　另一方面，產(chǎn)科醫(yī)四宮診察了想要早日回歸職場(chǎng)的職業(yè)女性佐野彩加。彩加向四宮詢問(wèn)自己是否可以按照預(yù)產(chǎn)期進(jìn)行生產(chǎn)，但四宮卻并沒(méi)有回答她，而是專心地做著B(niǎo)超檢查。檢查的結(jié)果，彩加的寶寶患有“心室中隔欠損”，是一種心臟上有小孔的疾病。彩加因此十分動(dòng)搖，圍產(chǎn)期中心的負(fù)責(zé)人今橋與四宮一起向彩加的丈夫康孝仔細(xì)傳達(dá)了這件事。想要早日回歸職場(chǎng)的彩加的心情與寶寶的疾病交織在一起，帶來(lái)了雙重不安。
　　而愛(ài)菜在生產(chǎn)前，也向櫻闡述了自己的不安……

上世紀(jì)六十年代，在“黑云壓城城欲摧”的國(guó)際形勢(shì)下，毛主席一聲號(hào)令：好人好馬上三線！ 軍人后代張利軍、農(nóng)民的兒子馬朝陽(yáng)、“資本家千金”陸若文和留蘇歸來(lái)的向晴等這些充滿斗志和激情的年輕人，來(lái)到了大西南的崇山峻嶺，用生命和青春實(shí)踐自己的理想同時(shí)，又演繹著牽腸掛肚的愛(ài)情角逐。張利軍一直愛(ài)慕陸若文，但陸若文因?yàn)閼?zhàn)友加閨蜜向晴非張利軍不嫁，便與殷勤周到、但城府頗深的梁玉強(qiáng)結(jié)婚了。就在張利軍慢慢接受向晴并準(zhǔn)備結(jié)婚時(shí)，向晴卻在爆炸事故中犧牲了。梁玉強(qiáng)和“出身不好”的陸若文離了婚，張利軍和陸若文在經(jīng)過(guò)無(wú)數(shù)坎坷經(jīng)歷后，終于舉行了婚禮。改革開(kāi)放后，張利軍任軍工廠長(zhǎng)，馬朝陽(yáng)任航天科技研究院院長(zhǎng)。高占武被查出胃癌，但仍然駐守在設(shè)計(jì)室和車(chē)間。陸若文、馬朝陽(yáng)、張利軍、向晴、高占武他們?cè)谝黄纳揭暗?，?xiě)下了中國(guó)國(guó)防工業(yè)建設(shè)輝煌的篇章。他們是斗士，把青春、愛(ài)情、終身以及他們的子孫奉獻(xiàn)給了三線，卻寂靜得象無(wú)人問(wèn)津的山谷。

余英偉（黎耀祥 飾）和李名揚(yáng)（陳豪 飾）都是能言善辯大名鼎鼎的律師，兩人一路走來(lái)一路斗，在一場(chǎng)游艇官司中站到了對(duì)立面。更巧的是，住持這場(chǎng)官司的法官，竟然是兩人共同的舊情人陸思凝（伍詠薇 飾）。

　　At the beginning of the season Sylvia becomes pregnant with Andy's child. A baby boy, Theo, is born towards the end of the season. This is contrasted with the fate that awaits Sipowicz's older son, Andy Jr., who announces that he is to join the police force. Andy is finally bonding with his estranged son when he is gunned down, which leads the elder Sipowicz to fall off the wagon. Andy Jr's murderers are killed themselves by Simone in an act of self defense.
　　Bobby and Diane, whose relationship had been put on hold while she attended AA, resume their relationship only for Diane to begin drinking again when her abusive father beats her mother. Her father is eventually killed and her mother becomes the prime suspect.
　　James Martinez and new detective Adrienne Lesniak begin an affair but only after Lesniak tells Medavoy that she is gay, then that she is not; Martinez later breaks up with her due to her controlling and unpleasant behavior, and Lesniak eventually leaves the squad. Medavoy himself leaves his wife, recognizing that she is holding him back but it is too late to save his relationship with Donna who leaves to take up a job with Apple.

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