A scientist performing illegal stem cell research is trying to find a cure for cancer. After the transfer of shark cells is made into a human test subject, the ill man gets well again and it looks like the treatment was a success. But the experiment goes wrong, and the man transforms into monster: half-shark & half-human. But the scientist knows how to use this to his advantage. He has invited some of his old pals to the island and is hoping to take revenge on them with his new creature. But do they have any tricks up their sleeve?

　　故事發(fā)生在美國馬里蘭州的巴爾的摩，西爾維婭（崔茜·尤瑪 Tracey Ullman 飾）和丈夫沃恩（克里斯·艾塞克 Chris Isaak 飾）結(jié)婚多年，兩人共同經(jīng)營著一間便利店。每一天，西爾維婭都要親手打理店里的上上下下，除此之外還要操心叛逆的女兒卡普萊斯（塞爾瑪·布萊爾 Selma Blair 飾），繁瑣的生活讓西爾維婭早已經(jīng)精疲力盡，沒有閑心來維系和丈夫之間的關(guān)系。
　　一場車禍讓西爾維婭患上了腦震蕩，但和普通的腦震蕩不同，西爾維婭的病情是以產(chǎn)生強烈的性沖動來表現(xiàn)的。自此之后，西爾維婭的性格變得越來越狂野和放蕩，這令起初竊竊自喜的沃恩漸漸感到有些力不從心。

黑幫老大艾迪?金策劃了一起兇殺案，被偶然路過的年輕人西恩?瓊斯（Nathan Phillips 飾）目擊。為了在法庭上成功指控這個作惡多端的黑社會頭子，警方派出資深聯(lián)邦密探尼維利?費恩（Samuel L. Jackson 飾）負責保護西恩，并將其從夏威夷護送至洛杉磯法庭。為避免證人遇害，尼維利采取聲東擊西的策略，與西恩偷偷乘上一架普通的紅眼航班。

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