名不見經傳的鋼琴家安迪（馬提亞斯·施維赫夫 Matthias Schweigh?fer 飾）和從未干過什么正經事整天游手好閑的本諾（弗洛里安·大衛(wèi)·菲茨 Florian David Fitz 飾），這兩個個性迥異似乎永遠都不會有交集的人，相識于病房之中，兩人都患上了無法治愈的絕癥，時日無多。
　　在本諾的慫恿之下，安迪決定和他一起逃出病房，來一趟充滿了陽光和激情的非洲之旅，他們要盡情享受轟轟烈烈毫無顧忌的人生，才能甘心接收死亡的終結。就這樣，兩個“亡命之徒”踏上了他們的旅途，一路上，瘋狂的兩人制造了數不清的麻煩和笑料，而他們糟糕的健康狀況，亦令兩人屢屢同死神擦肩而過。最終，當他們抵達了目的地時，又會有怎樣的一番景象在等待著兩人呢？

　　Anna is stuck: she's approaching 30, living like a hermit in her mum's garden shed and wondering why the suffragettes ever bothered. She spends her days making videos using her thumbs as actors - thumbs that bicker about things like whether Yogi Bear is a moral or existential nihilist. But Anna doesn't show these videos to anyone and no one knows what they are for. A week before her birthday her Mum serves her an ultimatum - she needs to move out of the shed, get a haircut that doesn't put her gender in question and stop dressing like a homeless teenager. Naturally, Anna tells her Mum to "back the f-off". However, when her school friend comes to visit, Anna's self-imposed isolation becomes impossible to maintain. Soon she is entangled with a troubled eight year old boy obsessed with Westerns, and the local estate agent whose awkward interpersonal skills continually undermine his attempts to seduce her.

當兩個在大峽谷徒步旅行的好朋友信任一位經驗豐富的徒步導游帶他們進行越野探險時，當他俘虜他們時，事情就向南發(fā)展了，他們必須與人類和自然作斗爭才能活著離開峽谷。