Miss Happy stars Pancake Khemanit as a happy-go-lucky woman named Happy, who often annoys her best friend Golfie (Ben Chalatit). Unfortunately, Happy is diagnosed with having an irregular heartbeat that will likely cause her death within a month. In an effort to survive, Happy looks up information and finds a YouTube video made by Tul, played by Jitpanu Klomkaew (Ball). Tul's video claims that Happy can stay alive if she dances in the way shown in the video.

　　法蘭克是一個普通的上班族，在30歲的生日前夕，他的上司馬克委托他代為照顧10歲兒子雷米。但法蘭克的好友們，早已為他精心籌備一場狂歡派對，大伙將計就計直接到馬克家舉辦派對，決定一邊當保姆一邊party！
　　隔天馬克接到警方的電話，發(fā)現(xiàn)法蘭克跟雷米雙雙失蹤，整個家里被搞得天翻地覆，唯一的線索是現(xiàn)場遺留下的一臺DV……

　　鐵橋三(劉家勇 飾)發(fā)覺林縣官與鎮(zhèn)南醫(yī)局主持孟平(湯錦棠 飾)勾結販毒，被追殺，幸得漁家女采嬌(惠英紅 飾)所救。采嬌乾爹醉公公(黃蝦 飾)介紹鐵到歐陽洪的雜貨店送貨，因而認識酒樓伙計老鼠仔(岑潛波 飾)。林與孟查知鐵下落，欲加害鐵，反而使歐陽洪無辜被害。鐵逃入海幢寺，得玄光大師傳授五郎八卦棍，遂與老鼠仔往找孟平報仇……